自发性脑出血的遗传因素及其分子机制的研究进展

自发性脑出血(SICH)是指原发性、非外伤性脑实质内出血,在我国约占全部脑卒中的20%-30%,是一种受环境和遗传等多重因素共同影响的疾病。其高致残率及病死率严重危害着人类的健康。因此,找到SICH的发病原因及危险因素具有重要意义。本文主要从遗传学及分子生物学的角度对SICH的发生机制的研究进展作一综述。...

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Published in天津医药 Vol. 43; no. 7; pp. 818 - 821
Main Author 刘洋 刘秀 陈旭义 孙圣凯 王志宏
Format Journal Article
LanguageChinese
Published 辽宁医学院武警后勤学院附属医院培养基地 邮编300162%天津市神经创伤修复重点实验室%武警后勤学院附属医院 2015
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Summary:自发性脑出血(SICH)是指原发性、非外伤性脑实质内出血,在我国约占全部脑卒中的20%-30%,是一种受环境和遗传等多重因素共同影响的疾病。其高致残率及病死率严重危害着人类的健康。因此,找到SICH的发病原因及危险因素具有重要意义。本文主要从遗传学及分子生物学的角度对SICH的发生机制的研究进展作一综述。
Bibliography:LIU Yang, LIU Xiu, CHEN Xuyi, SUN Shengkai, WANG Zhihong( 1 Affiliated Hospital of Logistics University of Chinese Armed Police Forces (CAPF), Training Base of Liaoning Medical University, Tianjin 300162, China; 2 Tianjin Key Laboratory of Neurotrauma ; 3 Affiliated Hospital of Logistics University of Chinese Armed Police Forces (CAPF))
Spontaneous intracerebral hemorrhage(SICH) refers the primary, non-traumatic parenchymal hemorrhage.In China, SICH accounts for about 20%-30% of total strokes. SICH is a kind of disease affected by multiple factors includ-ing environmental and genetic factors. The high morbidity and mortality cause serious damage to human health. Therefore, itis important to find etiology and risk factors of SICH. The article reviewed the progress of SICH pathogenesis in the perspec-tive of genetics and molecular biology.
cerebral hemorrhage; genetic polymorphism; pathogenesis; smolecular mechanisms; genetic factors; review
12-1116/R
ISSN:0253-9896
DOI:10.11958/j.issn.0253-9896.2015.07.032