Normal-Phase HPLC Enantioseparation of Novel Chiral Metal Tetrahedrane-type Clusters on an Amylose-based Chiral Stationary Phase

In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthe...

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Published inAnalytical Sciences Vol. 21; no. 2; pp. 125 - 128
Main Authors WANG, Xia, LI, Wen-zhi, ZHAO, Quan-yi, LI, Yong-min, CHEN, Li-ren
Format Journal Article
LanguageEnglish
Published Japan The Japan Society for Analytical Chemistry 2005
Japan Science and Technology Agency
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Summary:In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), including its concentration and structure, and the structures of the clusters on the chiral separation and retention was investigated. The results suggest that not only the structure and concentration of alcohol in the mobile phase, but also the subtle structural differences in racemate can have a pronounced effect on the enantiomeric separation and retention.
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ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.21.125