Menstruation pulls the trigger for inflammation and pain in endometriosis

Highlights • Retrograde menstruation and endometriotic lesions release proinflammatory and pro-nociceptive mediators. • Retrograde menstruation is the trigger for inflammation and pain in endometriosis. • Targeting peripheral mechanisms in endometriosis-associated inflammatory pain may lead to impro...

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Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 36; no. 5; pp. 270 - 276
Main Authors Laux-Biehlmann, Alexis, d’Hooghe, Thomas, Zollner, Thomas M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2015
Subjects
Advanced Basic Science
endometriosis
Endometriosis - physiopathology
Female
Humans
Inflammation - physiopathology
inflammatory pain
Menstrual Cycle - immunology
Menstrual Cycle - metabolism
Menstrual Cycle - physiology
neurogenic inflammation
Nociceptive Pain - physiopathology
retrograde menstruation
sensory nerves
retrograde menstruation
endometriosis
inflammatory pain
neurogenic inflammation
sensory nerves
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Summary:Highlights • Retrograde menstruation and endometriotic lesions release proinflammatory and pro-nociceptive mediators. • Retrograde menstruation is the trigger for inflammation and pain in endometriosis. • Targeting peripheral mechanisms in endometriosis-associated inflammatory pain may lead to improved treatment. • Mechanisms causing inflammatory pain in endometriosis are relevant for other inflammatory disorders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2015.03.004