Evaluating active versus passive sources of human brucellosis in Jining City, China

• Published in: PeerJ (San Francisco, CA) Vol. 9; p. e11637
• Main Authors: Sun, Xihong, Jiang, Wenguo, Li, Yan, Li, Xiuchun, Zeng, Qingyi, Du, Juan, Yin, Aitian, Lu, Qing-Bin
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 22.06.2021; PeerJ, Inc; PeerJ Inc
• Subjects: Active and passive sources; Analysis; Brucellosis; Careers; Cattle; China; Cognitive ability; Contact history; Demography; Diagnosis; Disease control; Education; Epidemiology; Ethnicity; Fever; Food contamination & poisoning; Health care industry; Hospitals; Human brucellosis; Infection control; Infectious Diseases; Middle schools; Multivariate analysis; Performance evaluation; Public Health; Sheep; Software; Variables; China; Human brucellosis; Active and passive sources; Contact history; China
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.11637

Human brucellosis (HB) remains a serious public health concern owing to its resurgence across the globe and specifically in China. The timely detection of this disease is the key to its prevention and control. We sought to describe the differences in the demographics of high-risk populations with detected cases of HB contracted from active versus passive sources. We collected data from a large sample population from January to December 2018, in Jining City, China. We recruited patients that were at high-risk for brucellosis from three hospitals and Centers of Disease Control and Prevention (CDCs). These patients were classified into two groups: the active detection group was composed of individuals receiving brucellosis counseling at the CDCs; the passive detection group came from hospitals and high-risk HB groups. We tested a total of 2,247 subjects and 13.3% (299) presented as positive for HB. The positive rates for active and passive detection groups were 20.5% (256/1,249) and 4.3% (43/998), respectively ( p < 0.001). The detection rate of confirmed HB cases varied among all groups but was higher in the active detection group than in the passive detection group when controlled for age, sex, ethnicity, education, career, and contact history with sheep or cattle ( p < 0.05). Males, farmers, those with four types of contact history with sheep or cattle, and those presenting fever, hyperhidrosis and muscle pain were independent factors associated with confirmed HB cases in multivariate analysis of the active detection group. Active detection is the most common method used to detect brucellosis cases and should be applied to detect HB cases early and avoid misdiagnosis. We need to improve our understanding of brucellosis for high-risk populations. Passive HB detection can be supplemented with active detection when the cognitive changes resulting from brucellosis are low. It is important that healthcare providers understand and emphasis the timely diagnosis of HB.