Autoimmune Hepatitis Accompanied by Systemic Lupus Erythematosus

• Published in: Internal Medicine Vol. 43; no. 3; pp. 258 - 262
• Main Authors: TOJO, Jun, OHIRA, Hiromasa, ABE, Kazumichi, YOKOKAWA, Junko, TAKIGUCHI, Junko, RAI, Tsuyoshi, SHISHIDO, Shoichiro, SATO, Yukio, KASUKAWA, Reiji
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 01.03.2004; Japanese Society of Internal Medicine
• Subjects: Adult; anti-dsDNA antibodies; Antibodies, Antinuclear - analysis; Biological and medical sciences; corticosteroid; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Glucocorticoids - administration & dosage; Glucocorticoids - therapeutic use; Hepatitis, Autoimmune - complications; Hepatitis, Autoimmune - diagnosis; Hepatitis, Autoimmune - pathology; Humans; Liver - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; lupoid hepatitis; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - pathology; lupus hepatitis; Medical sciences; Necrosis; Other diseases. Semiology; Prednisolone - administration & dosage; Prednisolone - therapeutic use; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Autoimmunity; Immunopathology; Connective tissue disease; Skin disease; Hepatic disease; Autoimmune disease; anti-dsDNA antibodies; Medicine; Hepatitis; Systemic lupus erythematosus; lupus hepatitis; Systemic disease; corticosteroid; Digestive diseases; lupoid hepatitis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.43.258

We report a series of five patients with autoimmune hepatitis (AIH) accompanied by systemic lupus erythematosus (SLE) (AIH-SLE overlap). Serologic tests showed that all patients were positive for antinuclear antibody and double-stranded DNA antibody. Histological examination of the liver showed that three of the patients had chronic hepatitis with severe activity. One of the other two had acute and severe hepatitis with submassive necrosis in both portal and lobular areas. The last patient already had liver cirrhosis. All patients had a mild form of SLE and showed a rapid response to corticosteroid. There was no serious involvement of organs other than the liver in any of the patients, and the prognoses were comparatively good in all patients.