Induction of early decidualization by cadmium, a major contaminant of cigarette smoke

• Published in: Fertility and sterility Vol. 91; no. 4; pp. 1614 - 1617
• Main Authors: Tsutsumi, Ryo, M.D, Hiroi, Hisahiko, M.D., Ph.D, Momoeda, Mikio, M.D., Ph.D, Hosokawa, Yumi, M.D, Nakazawa, Fumiko, M.D., Ph.D, Yano, Tetstu, M.D., Ph.D, Tsutsumi, Osamu, M.D., Ph.D, Taketani, Yuji, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2009; Elsevier
• Subjects: Adult; Biological and medical sciences; Cadmium; Cadmium - toxicity; Cell Proliferation - drug effects; Cells, Cultured; Decidua - cytology; Decidua - drug effects; Decidua - metabolism; decidualization; Dose-Response Relationship, Drug; Endometrium - cytology; Endometrium - drug effects; Endometrium - metabolism; Female; Gynecology. Andrology. Obstetrics; Humans; IGFBP-1; Insulin-Like Growth Factor Binding Protein 1 - metabolism; Internal Medicine; Medical sciences; Middle Aged; Obstetrics and Gynecology; prolactin; Prolactin - metabolism; RNA, Messenger - metabolism; Smoking; Cadmium; IGFBP-1; prolactin; decidualization; Cigarette; Insulin like growth factor binding protein; Induction; Prolactin; Gynecology; Early; Triggering; Obstetrics; Decidualization
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2008.12.055

To investigate the effect of cadmium (Cd) contamination on endometrial function, human endometrial stromal cells were isolated and cultured with E2 plus P in the presence of Cd, a major contaminant in cigarette smoke, and assayed for PRL concentrations and its messenger RNA expression. Cd significantly increased PRL concentrations in the culture media and significantly up-regulated PRL messenger RNA expression of the endometrial stromal cells, suggesting that Cd stimulates decidualization of the endometrium and may disrupt endometrial environment, causing early decidualization.