Characteristics of the pediatric patients diagnosed with SARS-CoV-2 infection in a Romanian children's hospital: a retrospective study

• Published in: PeerJ (San Francisco, CA) Vol. 9; p. e11560
• Main Authors: Gavriliu, Liana-Cătălina, Murariu, Carmen, Potop, Vladimir, Spătaru, Radu
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 04.06.2021; PeerJ, Inc; PeerJ Inc
• Subjects: Age composition; Analysis; Asymptomatic; Children; Clinical and epidemiological characteristics; Coronaviruses; Cough; COVID-19; Curie, Marie; Curie, Marie (1867-1934); Disease transmission; Dyspnea; Emergency medical care; Epidemiology; Fever; Health aspects; Hematology; Hospitals; Independent sample; Infection; Infections; Infectious Diseases; Intensive care; Laboratories; Laboratory and radiological characteristics; Leukocytes; Lymphopenia; Monocytes; Pandemics; Patients; Pediatrics; Pneumonia; Risk groups; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Surveillance; Symptomatic and asymptomatic patients; Symptoms; Viral infections; China; Romania; Spain; Europe; COVID-19; Symptomatic and asymptomatic patients; Laboratory and radiological characteristics; Clinical and epidemiological characteristics; Symptoms
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.11560

To date, information on COVID-19 pediatric patients is still sparse. We aimed to highlight the epidemiological and clinical data regarding SARS-CoV-2 infection in children and adolescents to improve the understanding of the disease in this age group and inform physicians during the ongoing COVID-19 pandemic. We conducted a retrospective, observational study in "Marie Curie" Emergency Children's Hospital from Bucharest, Romania. We analyzed clinical and epidemiological characteristics of the patients confirmed with SARS-CoV-2 infection, between April 1, 2020-October 31, 2020. A total of 172 patients aged 0-18 years were included, 79 (45.93%) female and 93 (54.07%) male patients. 28 (16.28%) patients had co-morbidities (more often identified in asymptomatic group; < 0.0001). 47 (27.32%) had exposure to an identified source. 30 (17.44%) patients were asymptomatic; 142 (85.56%) had mild or moderate disease. The most frequent symptoms were: pyrexia (78.87%), digestive symptoms (50%), cough (40.14%). Chest X-ray was performed in 50 patients and it was abnormal in half of them, all being symptomatic. About 2/3 of the evaluated patients had normal leukocytes. The most common hematological change was lymphopenia; monocytes tended to be higher in symptomatic patients. About 40% of the patients were admitted; none required admission to ICU. No significant differences were found between symptomatic and asymptomatic patients regarding gender, age distribution, and exposure to a source. All the patients had asymptomatic, mild or moderate disease. Patients with comorbidities, classically considered high risk patients, presented the same pattern of disease.