Analysis of the VP2 protein gene of canine parvovirus strains from affected dogs in Japan

• Published in: Research in veterinary science Vol. 94; no. 2; pp. 368 - 371
• Main Authors: Soma, Takehisa, Taharaguchi, Satoshi, Ohinata, Tsuyoshi, Ishii, Hiroshi, Hara, Motonobu
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.04.2013; Elsevier Limited
• Subjects: Amino Acid Substitution; Animals; Canine parvovirus; Canine parvovirus 2; Capsid Proteins; Capsid Proteins - genetics; Capsid Proteins - metabolism; Carnivore protoparvovirus 1; Dog; Dog Diseases; Dog Diseases - epidemiology; Dog Diseases - virology; Dogs; epidemiology; evolution; Feline panleukopenia virus; Gene Expression Regulation, Viral; genes; genetics; Japan; Japan - epidemiology; metabolism; mutants; nucleotide sequences; Parvoviridae Infections; Parvoviridae Infections - epidemiology; Parvoviridae Infections - veterinary; Parvoviridae Infections - virology; Parvovirus, Canine; Parvovirus, Canine - genetics; Parvovirus, Canine - metabolism; Sequence; Taiwan; vaccines; veterinary; Veterinary medicine; virology; VP2; Japan; Taiwan; Canine parvovirus 2; VP2; Sequence; Dog; Japan
• ISSN: 0034-5288; 1532-2661; 1532-2661
• DOI: 10.1016/j.rvsc.2012.09.013

To clarify the evolution of canine parvovirus 2 (CPV-2) that has recently been epidemic in Japan, VP2 gene sequences at positions 3556–4166 were analyzed in 107 CPV-2 strains obtained from rectal swabs of diarrheic dogs from 2009 to 2011. CPV-2b (95 strains) was more frequently detected than CPV-2a (nine strains), while CPV-2c was not detected. Remaining three strains were identified as the original type CPV-2, which should be derived from vaccines. These findings are similar to the previous results involving Japanese strains, suggesting there has been no great change in the recent CPV-2 epidemic in Japan. This epidemic is the same as that in Taiwan. Furthermore, a 324-lle mutant, which has been reported in Korean and Chinese strains, was detected in 66.7% of CPV-2a strains.