Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma

Accumulating evidence demonstrates that circRNAs regulate diverse cellular processes and cancer progression. However, it remains unclear whether circRNAs play any functional role in esophageal squamous cell carcinoma (ESCC). The significance of circRNA_100876 in ESCC was analyzed by studying circRNA...

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Published inOncoTargets and therapy Vol. 11; pp. 7385 - 7394
Main Authors Cao, Sai, Chen, Guohao, Yan, Liumei, Li, Libo, Huang, Xianying
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2018
Taylor & Francis Ltd
Dove Medical Press
Subjects
Apoptosis
Biomarkers
Cancer metastasis
Carcinoma
Cell cycle
Esophageal cancer
Gastric cancer
Laboratory animals
Liver cancer
Lung cancer
Medical prognosis
Metastasis
Original Research
Pathogens
siRNA
Squamous cell carcinoma
Stem cells
Surgery
Thoracic surgery
United States > US
China
esophageal squamous cell carcinoma
circRNA_100876
epithelial—mesenchymal transition
metastasis
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Summary:Accumulating evidence demonstrates that circRNAs regulate diverse cellular processes and cancer progression. However, it remains unclear whether circRNAs play any functional role in esophageal squamous cell carcinoma (ESCC). The significance of circRNA_100876 in ESCC was analyzed by studying circRNA_100876 expression in ESCC tissues and the association between circRNA_100876 expression and clinicopathologic parameters. The biological effects of circRNA_100876 knockdown by lentivirus-mediated siRNAs on cell proliferation, cell cycle, apoptosis, and migration were investigated in vitro and in vivo. CircRNA_100876 expression was upregulated ( <0.05) and was negatively correlated with survival outcome ( <0.05) in ESCC. Inhibition of proliferation, migration, invasion, and epithelial-mesenchymal transition progression was confirmed after circRNA_100876 depletion. Dysregulation of circRNA_100876 expression leads to poor prognosis in ESCC by accelerating cell proliferation and metastasis.
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These authors contributed equally to this work
ISSN:1178-6930
1178-6930
DOI:10.2147/ott.s177524