Colorectal cancer development and advances in screening
Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorect...
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| Published in | Clinical interventions in aging Vol. 11; pp. 967 - 976 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New Zealand
Dove Medical Press Limited
01.01.2016
Taylor & Francis Ltd Dove Medical Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective. |
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| AbstractList | Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective. Karen Simon Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA Abstract: Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective. Keywords: colorectal cancer, DNA test, polyps, screening |
| Audience | Academic |
| Author | Balchen, Vanessa Simon, Karen |
| AuthorAffiliation | Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA |
| AuthorAffiliation_xml | – name: Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA |
| Author_xml | – sequence: 1 givenname: Vanessa surname: Balchen fullname: Balchen, Vanessa – sequence: 2 givenname: Karen surname: Simon fullname: Simon, Karen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27486317$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2016 Dove Medical Press Limited 2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Simon. This work is published and licensed by Dove Medical Press Limited 2016 |
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| Snippet | Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has... Karen Simon Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA Abstract: Most colon tumors develop via a multistep process involving a... |
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| SubjectTerms | Age Blood tests Cancer screening Care and treatment Colonography, Computed Tomographic Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Costs Deoxyribonucleic acid Diagnosis DNA DNA identification DNA methylation DNA test Early Detection of Cancer - methods Feces Gastroenterology Genetic Testing Humans Inflammatory bowel disease Mass Screening - methods Medical screening Morphology Morphology (Biology) Mortality polyps Polyps - diagnostic imaging Precancerous Conditions - diagnostic imaging Review Risk Factors screening Sigmoidoscopy Systematic review Tumors United States |
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| Title | Colorectal cancer development and advances in screening |
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