Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems

Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are a powerful weapon in the fight against bacteria. However, with the widespread use of antibiotics, the problem of drug resistance now poses a great threat to human health. In recent...

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Published inPharmaceutics Vol. 15; no. 4; p. 1188
Main Authors Yao, Jiaxin, Zou, Pengfei, Cui, Yanan, Quan, Liangzhu, Gao, Chunsheng, Li, Zhiping, Gong, Wei, Yang, Meiyan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2023
MDPI
Subjects
Antibiotics
Antimicrobial agents
antimicrobial materials
antimicrobial resistance
Apoptosis
Bacteria
Bacterial infections
Breast cancer
Care and treatment
Coronaviruses
COVID-19
Disease transmission
Drug delivery systems
Drug resistance
Drug resistance in microorganisms
Drug therapy
Drugs
E coli
Infections
Innovations
Membranes
Metabolism
multi-drug-resistant bacteria
Mutation
Penicillin
Permeability
Proteins
Public health
Review
RNA polymerase
Tumors
Vehicles
China
multi-drug-resistant bacteria
drug delivery systems
antimicrobial materials
antimicrobial resistance
antibiotics
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Summary:Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are a powerful weapon in the fight against bacteria. However, with the widespread use of antibiotics, the problem of drug resistance now poses a great threat to human health. In recent years, studies have investigated approaches to combat bacterial resistance. Several antimicrobial materials and drug delivery systems have emerged as promising strategies. Nano-drug delivery systems for antibiotics can reduce the resistance to antibiotics and extend the lifespan of novel antibiotics, and they allow targeting drug delivery compared to conventional antibiotics. This review highlights the mechanistic insights of using different strategies to combat drug-resistant bacteria and summarizes the recent advancements in antimicrobial materials and drug delivery systems for different carriers. Furthermore, the fundamental properties of combating antimicrobial resistance are discussed, and the current challenges and future perspectives in this field are proposed.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15041188