Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin

• Published in: Vaccine Vol. 31; no. 9; pp. 1334 - 1339
• Main Authors: Tanabe, Kazuyuki, Mita, Toshihiro, Palacpac, Nirianne M.Q, Arisue, Nobuko, Tougan, Takahiro, Kawai, Satoru, Jombart, Thibaut, Kobayashi, Fumie, Horii, Toshihiro
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 18.02.2013; Elsevier
• Subjects: adaptive immunity; Africa; Allergy and Immunology; AMA1; antigens; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Applied microbiology; Asia, Southeastern; Biological and medical sciences; clinical trials; CSP; DNA, Protozoan - chemistry; DNA, Protozoan - genetics; essential genes; Fundamental and applied biological sciences. Psychology; genetic variation; Human protozoal diseases; Humans; indigenous species; Infectious diseases; Life cycle. Host-agent relationship. Pathogenesis; Malaria; Malaria Vaccines - genetics; Malaria Vaccines - immunology; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - immunology; Merozoite Surface Protein 1 - genetics; Merozoite Surface Protein 1 - immunology; merozoites; Microbiology; Molecular Sequence Data; MSP1; Oceania; parasites; Parasitic diseases; pathogenesis; Phylogeography; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - immunology; Polymorphism, Single Nucleotide; Protozoa; Protozoal diseases; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Sequence Analysis, DNA; single nucleotide polymorphism; surface proteins; Vaccine; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); virulence; South East Asia; Pacific Ocean Islands; Sub-Saharan Africa; Asia, Southeastern; Africa; Oceania; ISEW, Southeast Asia; Plasmodium falciparum; CSP; AMA1; Vaccine; MSP1; Malaria; Origin; Protozoa; Apicomplexa; Protozoal disease; Genetic diversity; Parasitosis; Genetic vaccine; Population genetics; Infection; Antigen
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.12.039

Highlights ► Within-population SNP diversity in 3 antigen genes is due to geographic distance. ► Immune pressure may not greatly contribute to SNP diversity in Plasmodium falciparum antigens. ► Long term persistence of a large proportion of SNPs in the antigen genes.