Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 4; pp. 472 - 475
• Main Authors: Tregub, P. P., Kulikov, V. P., Motin, Yu. G., Nagibaeva, M. E., Zabrodina, A. S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain injuries; Cell Biology; Cell Hypoxia - physiology; Endoplasmic Reticulum - metabolism; Hypercapnia; Hypercapnia - metabolism; Hypercapnia - physiopathology; Internal Medicine; Ischemia; Laboratory Medicine; Male; Neurons; Neurons - metabolism; Neurons - physiology; Pathology; Rats; Rats, Wistar; Stroke; Stroke - metabolism; Stroke - physiopathology; Vascular endothelial growth factor; hypoxia; ischemic tolerance; stroke; endoplasmic reticulum; hypercapnia
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3441-z

We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and hypercapnia. Combined exposure to hypoxia and hypercapnia maximally increased the expression of chaperone GRP-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions, hypercapnia in combination with hypoxia is a priority factor for activation of GRP-78 and transcription factor NF-kB.