Residual curarization and postoperative respiratory complications following laparoscopic sleeve gastrectomy. The effect of reversal agents: sugammadex vs. neostigmine

• Published in: Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) Vol. 1; no. 2; pp. 61 - 67
• Main Authors: Ezri, Tiberiu, Evron, Shmuel, Petrov, Irina, Schachter, Pinhas, Berlovitz, Yitzhak, Shimonov, Mordechai
• Format: Journal Article
• Language: English
• Published: Poland De Gruyter Open 01.04.2015; Sciendo
• Subjects: muscle relaxants; neostigmine; respiratory complications; reversal; sugammadex; reversal; neostigmine; respiratory complications; sugammadex; muscle relaxants
• ISSN: 2393-1809; 2393-1817; 2393-1817
• DOI: 10.1515/jccm-2015-0009

Background: Incomplete muscle relaxant reversal or re-curarization may be associated with postoperative respiratory complications. In this retrospective study we compared the incidence of postoperative residual curarization and respiratory complications in association with the type of muscle relaxant reversal agent, sugammadex or neostigmine, in patients undergoing laparoscopic sleeve gastrectomy. Material and methods: We reviewed the charts of all patients (179) undergoing laparoscopic sleeve gastrectomy from July 2012 to July 2013 at Wolfson Medical Center. Sugammadex 1.5-2 mg/kg (112 patients) or neostigmine 2.5 mg (67 patients) were used as reversal agents. Results were compared by the type of reversal agent employed. Compared parameters included demographic and anaesthetic data, residual curarization, oxyhemoglobin saturation (SpO ) in the recovery room (PACU), episodes of SpO lower than 90% in PACU, unexpected intensive care (ICU) admissions, incidence of atelectasis and pneumonia, re-intubation and duration of hospitalization. Results: Obstructive sleep apnea syndrome (OSAS) was more frequent in the sugammadex group (19% vs. 8%; p = 0.026). Total intravenous anesthesia (TIVA) was more frequently associated with sugammadex (33% vs. 16%; p = 0.007). There were no differences in postoperative residual curarization, SpO < 90% episodes, reintubation, ICU admissions, pulmonary complications and duration of hospitalization. Conclusion: With the inherent limitations of a retrospective study, the use of sugammadex following laparoscopic sleeve gastrectomy showed no advantage over neostigmine in terms of residual curarization and respiratory complications.