Cerebroprotective and Regenerative Effects of Alkaloid Z77 under Conditions of Brain Ischemia

We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of cerebral ischemia. Pronounced cerebroprotective effect was found consisting in normalization of the orienting and exploratory activity and conditioned behavior associated with significant correction...

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Published inBulletin of experimental biology and medicine Vol. 158; no. 3; pp. 352 - 355
Main Authors Zyuz’kov, G. N., Suslov, N. I., Losev, E. A., Ermolaeva, L. A., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Simanina, E. V., Demkin, V. P., Povet’eva, T. N., Nesterova, Yu. V., Udut, V. V., Minakova, M. Yu, Dygai, A. M.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.01.2015
Springer
Springer Nature B.V
Subjects
Alkaloids
Alkaloids - therapeutic use
Animals
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - drug therapy
Cell Biology
Cerebral ischemia
Internal Medicine
Laboratory Medicine
Male
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neuroprotective Agents - therapeutic use
Pathology
Rats
Regenerative Medicine - methods
Stem cells
neural stem cells
regenerative medicine
cerebroprotective drugs
cerebral ischemia
alkaloids
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Summary:We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of cerebral ischemia. Pronounced cerebroprotective effect was found consisting in normalization of the orienting and exploratory activity and conditioned behavior associated with significant correction of morphological changes in the brain. The direct stimulatory effect of Z77 on neural stem cells was shown in vitro .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2760-9