Anxiolytic and Antidepressant Effects of Divaza and Brizantin

• Published in: Bulletin of experimental biology and medicine Vol. 159; no. 6; pp. 753 - 756
• Main Authors: Yakovleva, N. N., Voronina, T. A., Suslov, N. I., Ertuzun, I. A., Molodavkin, G. M., Poseva, V. I., Andreeva, V. V., Dugina, Yu. L., Putilovskii, M. A., Epshtein, O. I.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2015; Springer; Springer Nature B.V
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Antianxiety agents; Antibodies; Antibodies - pharmacology; Antidepressants; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biomedical and Life Sciences; Biomedicine; Brain - drug effects; Cell Biology; Diazepam - pharmacology; Drug Combinations; Drug Evaluation, Preclinical; Internal Medicine; Laboratory Medicine; Male; Maze Learning - drug effects; Motor Activity - drug effects; Pathology; Rats; Stress, Psychological - pathology; Swimming - psychology; anxiolytic effect; S100; brizantin; divaza; antidepressant effect
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-3067-6

The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of brizantin in a dose of 2.5 ml/kg and divaza in a dose of 7.5 ml/kg significantly increased punished drinking in the Vogel conflict test in comparison with the control. Both drugs also improved general emotional behavior during training prior to the test procedure. Brizantin and divaza in a dose of 7.5 ml/kg increased the number of wheel revolutions in the Nomura forced swimming test in comparison with the control; the effect of divaza was more pronounced. High correlation coefficients between the number of wheel revolutions during the first and second 5-min sessions are also indicative of antidepressant action of divaza and brizantin.