NLRC5: a key regulator of MHC class I-dependent immune responses
The identification of NLRC5 as a transcriptional transactivator of MHC class I genes has shed light on the regulation of MHC class I expression. This Progress article summarizes the recent advances in the field and highlights some of the questions that still remain to be addressed. The expression of...
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Published in | Nature reviews. Immunology Vol. 12; no. 12; pp. 813 - 820 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.12.2012
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | The identification of NLRC5 as a transcriptional transactivator of MHC class I genes has shed light on the regulation of MHC class I expression. This Progress article summarizes the recent advances in the field and highlights some of the questions that still remain to be addressed.
The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1 |
ISSN: | 1474-1733 1474-1741 |
DOI: | 10.1038/nri3339 |