Serum Levels of 8-Hydroxy-2’-Deoxyguanosine DNA in Patients with Breast Cancer and Endometrial Cancer with and without Diabetes Mellitus

Blood levels of 8-hydroxy-2’-deoxyguanosine (8-OHdG) were measured by enzyme immunoassay after overnight fasting in untreated breast cancer and endometrial cancer patients ( N =170) of mainly postmenopausal age with and without type 2 diabetes mellitus. The concentrations of 8-OHdG in patients with...

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Published inBulletin of experimental biology and medicine Vol. 161; no. 4; pp. 547 - 549
Main Authors Berstein, L. M., Poroshina, T. E., Kovalenko, I. M., Vasilyev, D. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2016
Springer
Springer Nature B.V
Subjects
Adult
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Breast cancer
Breast Neoplasms - blood
Cancer genetics
Cancer patients
Cancer research
Care and treatment
Cell Biology
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
Diabetes Mellitus, Type 2 - blood
Diabetics
DNA
Endometrial cancer
Endometrial Neoplasms - blood
Enzymes
Female
Humans
Internal Medicine
Laboratory Medicine
Middle Aged
Pathology
Postmenopausal women
Type 2 diabetes
diabetes
8-hydroxy-2’-deoxyguanosin
cancer
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Summary:Blood levels of 8-hydroxy-2’-deoxyguanosine (8-OHdG) were measured by enzyme immunoassay after overnight fasting in untreated breast cancer and endometrial cancer patients ( N =170) of mainly postmenopausal age with and without type 2 diabetes mellitus. The concentrations of 8-OHdG in patients with breast cancer were higher than in patients with endometrial cancer and in patients with breast cancer and diabetes in comparison with patients with breast cancer without diabetes. No correlations of blood 8-OHdG levels with glycemia, age, and clinical stage of disease were detected. In cancer patients with diabetes, the concentration of 8-OHdG increases proportionally to the increase in body mass index, though this does not lead to disappearance of the above differences between patients with breast cancer and endometrial cancer by the level of 8-OHdG. The causes of the trend to a less favorable course of tumor process in patients with breast cancer and diabetes in comparison with endometrial cancer and diabetes deserve further studies.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3457-4