pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pec...

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Published inPharmaceutics Vol. 15; no. 3; p. 816
Main Authors Juthi, Ajkia Zaman, Li, Fenfen, Wang, Bo, Alam, Md Mofasserul, Talukder, Md Eman, Qiu, Bensheng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2023
MDPI
Subjects
Controlled release technology
controlled-release drug delivery
Drug delivery systems
Ethanol
Gastrointestinal system
gastroretentive
Gels (Pharmacy)
Hydrogels
Materials
Mechanical properties
Physiological aspects
Polymerization
Polymers
super-porous hybrid hydrogels
China
super-porous hybrid hydrogels
controlled-release drug delivery
gastroretentive
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Abstract Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.
AbstractList Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs-improved elasticity, pH responsivity, and high swelling performance-should be investigated for broader drug delivery applications in the future.
Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs-improved elasticity, pH responsivity, and high swelling performance-should be investigated for broader drug delivery applications in the future.Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs-improved elasticity, pH responsivity, and high swelling performance-should be investigated for broader drug delivery applications in the future.
Audience Academic
Author Li, Fenfen
Wang, Bo
Juthi, Ajkia Zaman
Alam, Md Mofasserul
Qiu, Bensheng
Talukder, Md Eman
AuthorAffiliation 3 School of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China
1 School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, China
5 Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511400, China
2 Center for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, China
4 School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230026, China
AuthorAffiliation_xml – name: 1 School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, China
– name: 3 School of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China
– name: 2 Center for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, China
– name: 4 School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230026, China
– name: 5 Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511400, China
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  givenname: Ajkia Zaman
  orcidid: 0000-0003-1650-3676
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controlled-release drug delivery
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Snippet Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper...
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StartPage 816
SubjectTerms Controlled release technology
controlled-release drug delivery
Drug delivery systems
Ethanol
Gastrointestinal system
gastroretentive
Gels (Pharmacy)
Hydrogels
Materials
Mechanical properties
Physiological aspects
Polymerization
Polymers
super-porous hybrid hydrogels
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Title pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
URI https://www.ncbi.nlm.nih.gov/pubmed/36986676
https://www.proquest.com/docview/2791700401
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Volume 15
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