pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pec...

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Published inPharmaceutics Vol. 15; no. 3; p. 816
Main Authors Juthi, Ajkia Zaman, Li, Fenfen, Wang, Bo, Alam, Md Mofasserul, Talukder, Md Eman, Qiu, Bensheng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2023
MDPI
Subjects
Controlled release technology
controlled-release drug delivery
Drug delivery systems
Ethanol
Gastrointestinal system
gastroretentive
Gels (Pharmacy)
Hydrogels
Materials
Mechanical properties
Physiological aspects
Polymerization
Polymers
super-porous hybrid hydrogels
China
super-porous hybrid hydrogels
controlled-release drug delivery
gastroretentive
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Summary:Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15030816