Heritable functional architecture in human visual cortex

• Published in: NeuroImage (Orlando, Fla.) Vol. 239; p. 118286
• Main Authors: Alvarez, Ivan, Finlayson, Nonie J., Ei, Shwe, de Haas, Benjamin, Greenwood, John A., Schwarzkopf, D. Samuel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2021; Elsevier Limited; Academic Press; Elsevier
• Subjects: Adolescent; Adult; Biological Variation, Individual; Brain Mapping; Female; Functional magnetic resonance imaging; Functional morphology; Gene mapping; Heritability; Humans; Information processing; Magnetic Resonance Imaging; Male; Middle Aged; Morphology; Neuroimaging; Photic Stimulation; Population genetics; Population receptive fields; Quantitative Trait, Heritable; Questionnaires; Receptive field; Retina; Retinotopic mapping; Twin studies; Twin study; Twins; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics; Visual cortex; Visual Cortex - anatomy & histology; Visual Cortex - physiology; Visual Fields - genetics; Visual processing; Visual stimuli; Visual system; Young Adult; Retinotopic mapping; Visual processing; Visual cortex; Population receptive fields; Heritability; Twin study
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118286

•We analyzed retinotopic maps from monozygotic and dizygotic twin pairs.•Visual field maps in V1-V3 are more similar in monozygotic twins.•Heritability is greater in V1 and V3 for polar angle and population receptive field sizes.•Eccentricity maps show lesser degree of heritability.•Further evidence for link between cortical morphology and topology of retinotopic maps. How much of the functional organization of our visual system is inherited? Here we tested the heritability of retinotopic maps in human visual cortex using functional magnetic resonance imaging. We demonstrate that retinotopic organization shows a closer correspondence in monozygotic (MZ) compared to dizygotic (DZ) twin pairs, suggesting a partial genetic determination. Using population receptive field (pRF) analysis to examine the preferred spatial location and selectivity of these neuronal populations, we estimate a heritability around 10–20% for polar angle preferences and spatial selectivity, as quantified by pRF size, in extrastriate areas V2 and V3. Our findings are consistent with heritability in both the macroscopic arrangement of visual regions and stimulus tuning properties of visual cortex. This could constitute a neural substrate for variations in a range of perceptual effects, which themselves have been found to be at least partially genetically determined. These findings also add convergent evidence for the hypothesis that functional map topology is linked with cortical morphology. [Display omitted]