Correlation of clinicopathological and prognostic characteristics between endometriosis-associated and primary ovarian cancer

• Published in: BMC cancer Vol. 23; no. 1; p. 1210
• Main Authors: Wang, Huimin, Chen, Cong, Wang, Danbo, Zhu, Yanmei, Chen, Peng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.12.2023; BioMed Central; BMC
• Subjects: Adenocarcinoma, Clear Cell - pathology; Age; Analysis; Ascites; Biomarkers; Body mass index; Cancer therapies; Care and treatment; Chemotherapy; Clinical pathology; Comparative analysis; Complications and side effects; Diagnostic criteria; Endometrial cancer; Endometriosis; Endometriosis - complications; Endometriosis - diagnosis; Endometriosis-associated ovarian cancer; Female; Health aspects; Humans; Malignancy; Menopause; Metastasis; Mortality; Neoplasm Recurrence, Local - complications; Ovarian cancer; Ovarian clear cell carcinoma; Ovarian endometrioid carcinoma; Ovarian Neoplasms - metabolism; Patients; Post-menopause; Postmenopausal women; Prevention; Prognosis; Retrospective Studies; Risk factors; Social aspects; Surgery; Survival analysis; Tumor proteins; Tumors; China; Ovarian clear cell carcinoma; Ovarian endometrioid carcinoma; Diagnostic criteria; Endometriosis-associated ovarian cancer
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-023-11641-4

The main aim of this study was to establish the clinicopathological and prognostic correlations between endometriosis-associated and non-endometriosis-associated primary ovarian cancer, with a view to providing a reference guide for revision of diagnostic criteria for malignant transformation of endometriosis. Clinicopathological and follow-up data of 174 patients with clear cell and endometrial ovarian cancer were retrospectively extracted. Cases were divided into endometriosis-associated and non-endometriosis-associated primary ovarian cancer for comparative analysis of clinicopathological characteristics and prognosis. Average age and post-menopausal rate in the endometriosis-associated ovarian cancer group were lower relative to the primary ovarian cancer group (P < 0.05). Body mass index, age at menopause, operation history, dysmenorrhea, complications, tumor size, tumor side, ascites, CA125, HE4, CA19.9, stage, differentiation, expression of ER, PR, P53, P16, Ki67, MMR, HNF-1β and Napsin A were not significantly different between the groups (P > 0.05). Furthermore, rates of resistance to platinum chemotherapy, relapse, progression-free survival and overall survival were comparable between the two groups (P > 0.05). Endometriosis-associated and primary ovarian cancers of the same pathological type are speculated to be homologous in terms of origin from malignant transformation of endometriosis. It may therefore be necessary to revise the diagnostic criteria for ovarian endometriosis malignancy.