Evidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients

• Published in: Biological psychiatry (1969) Vol. 71; no. 7; pp. 611 - 617
• Main Authors: Zhu, Xueling, Wang, Xiang, Xiao, Jin, Liao, Jian, Zhong, Mingtian, Wang, Wei, Yao, Shuqiao
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Autobiological memory; Biological and medical sciences; Case-Control Studies; default mode network; Depression; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Female; Functional Neuroimaging - methods; Functional Neuroimaging - psychology; Humans; independent component analysis; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - psychology; major depressive disorder; Male; Medical sciences; Memory, Episodic; Mood disorders; Neural Pathways - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rest - physiology; resting-state; rumination; Thinking - physiology; independent component analysis; major depressive disorder; default mode network; rumination; resting-state; Autobiological memory; Mood disorder; Human; Memory; Central nervous system; Depression; Encephalon; Rest; Treatment; First episode; Dissociation; Rumination
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2011.10.035

Imaging studies have shown that major depressive disorder (MDD) is associated with altered activity patterns of the default mode network (DMN). However, the neural correlates of the resting-state DMN and MDD-related pathopsychological characteristics, such as depressive rumination and overgeneral autobiographical memory (OGM) phenomena, still remain unclear. Using independent component analysis, we analyzed resting-state functional magnetic resonance imaging data obtained from 35 first-episode, treatment-naive young adults with MDD and from 35 matched healthy control subjects. Patients with MDD exhibited higher levels of rumination and OGM than did the control subjects. We observed increased functional connectivity in the anterior medial cortex regions (especially the medial prefrontal cortex and anterior cingulate cortex) and decreased functional connectivity in the posterior medial cortex regions (especially the posterior cingulate cortex/precuneus) in MDD patients compared with control subjects. In the depressed group, the increased functional connectivity in the anterior medial cortex correlated positively with rumination score, while the decreased functional connectivity in the posterior medial cortex correlated negatively with OGM score. We report dissociation between anterior and posterior functional connectivity in resting-state DMNs of first-episode, treatment-naive young adults with MDD. Increased functional connectivity in anterior medial regions of the resting-state DMN was associated with rumination, whereas decreased functional connectivity in posterior medial regions was associated with OGM. These results provide new evidence for the importance of the DMN in the pathophysiology of MDD and suggest that abnormal DMN activity may be an MDD trait.