Distribution of Cyclocytidine in Tissues

The distribution and changes of concentration of cyclocytidine in tissues with time were quantitatively examined after intravenous injection or oral administration. Localized distribution of the compound in tissues was confirmed quantitatively and retention of the compound in most of the tissues tes...

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Published inChemical & pharmaceutical bulletin Vol. 23; no. 4; pp. 725 - 728
Main Authors HOSHI, AKIO, IIGO, MASAAKI, KURETANI, KAZUO, KANAI, TADASHI, ICHINO, MOTONOBU
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1975
Japan Science and Technology Agency
Subjects
Animals
Cytarabine - analogs & derivatives
Cytarabine - metabolism
Female
Kidney - metabolism
Liver - metabolism
Mice
Muscles - metabolism
Rats
Salivary Glands - metabolism
Time Factors
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Summary:The distribution and changes of concentration of cyclocytidine in tissues with time were quantitatively examined after intravenous injection or oral administration. Localized distribution of the compound in tissues was confirmed quantitatively and retention of the compound in most of the tissues tested was found out. Whereas, aracytidine distributed uniformly in tissues and elimination rate of the compound from tissues was similar in each other. After oral administration, cyclocytidine distributed in various tissues at very low levels.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.23.725