Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans

The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining them from a widely distributed and renewable source, makes them attractive novel bioa...

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Published inPharmaceutics Vol. 15; no. 3; p. 808
Main Authors Flórez-Fernández, Noelia, Vaamonde-García, Carlos, Torres, Maria Dolores, Buján, Manuela, Muíños, Alexandra, Muiños, Antonio, Lamas-Vázquez, María J, Meijide-Faílde, Rosa, Blanco, Francisco J, Domínguez, Herminia
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2023
MDPI
Subjects
Acids
Algae
Alzheimer's disease
Anti-inflammatory drugs
brown seaweed
Cancer therapies
Cytokines
Diabetes
Drugs
Enzymes
extraction
Extraction (Chemistry)
Immune system
Inflammation
Influence
Kinases
Review
Structure
sulphated polysaccharides
Transcription factors
Spain
brown seaweed
sulphated polysaccharides
extraction
inflammation
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Summary:The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining them from a widely distributed and renewable source, makes them attractive novel bioactives. However, fucoidans' heterogeneity and variability in composition, structure, and properties depending on seaweed species, biotic and abiotic factors and processing conditions, especially during extraction and purification stages, make it difficult for standardization. A review of the available technologies, including those based on intensification strategies, and their influence on fucoidan composition, structure, and anti-inflammatory potential of crude extracts and fractions is presented.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15030808