Methodological issues in the design of a rheumatoid arthritis activity score and its cut-offs

Activity of rheumatoid arthritis (RA) can be evaluated using several scoring scales based on clinical features. The most widely used one is the Disease Activity Score involving 28 joint counts (DAS28) for which cut-offs were proposed to help physicians classify patients. However, inaccurate scoring...

Full description

Saved in:
Bibliographic Details
Published inClinical epidemiology Vol. 6; no. default; pp. 221 - 226
Main Author Collignon, Olivier
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2014
Taylor & Francis Ltd
Dove Medical Press
Subjects
Clinical medicine
Clinical trials
Diagnosis
Epidemiology
Experts
Health risk assessment
Methodology
Methods
Musculoskeletal tests
Patients
Physicians
Rheumatism
Rheumatoid arthritis
Rheumatology
Survival analysis
New York
United States > US
DAS28
modeling
clinical prediction
penalized logistic regression
disease activity score
Online AccessGet full text

Cover

More Information
Summary:Activity of rheumatoid arthritis (RA) can be evaluated using several scoring scales based on clinical features. The most widely used one is the Disease Activity Score involving 28 joint counts (DAS28) for which cut-offs were proposed to help physicians classify patients. However, inaccurate scoring can lead to inappropriate medical decisions. In this article some methodological issues in the design of such a score and its cut-offs are highlighted in order to further propose a strategy to overcome them. As long as the issues reviewed in this article are not addressed, results of studies based on standard disease activity scores such as DAS28 should be considered with caution.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1179-1349
1179-1349
DOI:10.2147/CLEP.S64811