Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective

• Published in: Thrombosis research Vol. 125; no. 2; pp. 112 - 118
• Main Authors: Bogdanov, Vladimir Y., Østerud, Bjarne
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.02.2010; Elsevier
• Subjects: Associated diseases and complications; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; cardiovascular complications; Cardiovascular Diseases - blood; diabetes; Diabetes Complications - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Hematology, Oncology and Palliative Medicine; Humans; Medical sciences; Thromboplastin - metabolism; Tissue Factor; Tissue Factor; cardiovascular complications; diabetes; Endocrinopathy; Diabetes mellitus; Tissue factor; Complication; Cardiovascular disease
• ISSN: 0049-3848; 1879-2472; 1879-2472
• DOI: 10.1016/j.thromres.2009.06.033

Heightened activity of circulating Tissue Factor (TF) has been linked to a variety of macro- and microvascular cardiovascular complications commonly observed in diabetes mellitus. Systemic and localized vascular abnormalities comprise the most debilitating feature of diabetic pathophysiology. Blood monocytes are chronically activated in diabetes, and serve as the major source of bioactive intravascular TF. This review examines recent literature on this subject, with a special emphasis on the abnormal monocyte physiology in diabetes and the structural and functional diversity of circulating TF.