Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia: Opportunities, Challenges, and Recommendations for Physical Activity Interventions

• Published in: Clinical interventions in aging Vol. 15; pp. 1675 - 1690
• Main Authors: Billot, Maxime, Calvani, Riccardo, Urtamo, Annele, Sánchez-Sánchez, Juan Luis, Ciccolari-Micaldi, Cecilia, Chang, Milan, Roller-Wirnsberger, Regina, Wirnsberger, Gerhard, Sinclair, Alan, Vaquero-Pinto, María Nieves, Jyväkorpi, Satu, Öhman, Hanna, Strandberg, Timo, Schols, Jos MGA, Schols, Annemie MWJ, Smeets, Nick, Topinkova, Eva, Michalkova, Helena, Bonfigli, Anna Rita, Lattanzio, Fabrizia, Rodríguez-Mañas, Leocadio, Coelho, Hélio, Broccatelli, Marianna, D'Elia, Maria Elena, Biscotti, Damiano, Marzetti, Emanuele, Freiberger, Ellen
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Accidental Falls - prevention & control; Age; Aged; Aging; Aging - physiology; balance; better aging; Care and treatment; Exercise; Exercise - physiology; Frail elderly; Frail Elderly - statistics & numerical data; Frailty; Frailty - physiopathology; Frailty - rehabilitation; Gait; Growth factors; Humans; Mobility; Mortality; muscle mass; Muscular system; Nervous system; Older people; Osteoporosis; physical exercise; Physical fitness; Physically disabled persons; Physiology; Population; Postural Balance - physiology; Quality of Life; Review; Sarcopenia; Sarcopenia - physiopathology; Sarcopenia - rehabilitation; strength; walking; Womens health; France; muscle mass; better aging; balance; strength; physical exercise; walking
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S253535

One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.