Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water‐soluble polyaniline nanoparticles was red‐shifted to a near‐infrared (NIR) wavelength as a result of the formation of the...

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Published inAngewandte Chemie (International ed.) Vol. 50; no. 2; pp. 441 - 444
Main Authors Yang, Jaemoon, Choi, Jihye, Bang, Doyeon, Kim, Eunjung, Lim, Eun-Kyung, Park, Huiyul, Suh, Jin-Suck, Lee, Kwangyeol, Yoo, Kyung-Hwa, Kim, Eun-Kyung, Huh, Yong-Min, Haam, Seungjoo
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 10.01.2011
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Aniline Compounds - chemistry
Animals
cancer
Cell Line, Tumor
Humans
Hydrogen-Ion Concentration
Infrared Rays
Mice
Mice, Nude
nanoparticles
Nanoparticles - chemistry
near-infrared light
Neoplasms - pathology
Neoplasms - therapy
photothermal agents
polymers
Spectroscopy, Near-Infrared
Temperature
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Summary:Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water‐soluble polyaniline nanoparticles was red‐shifted to a near‐infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo.
Bibliography:http://dx.doi.org/10.1002/anie.201005075
This research was supported by the KOSEF grant funded by MOST (No. M10755020001-07N5502-00110), the Korean Health Technology R&D Project, Ministry of Health, Welfare & Family Affairs (A101954), and the KRIBB Research Initiative Program.
KOSEF
ArticleID:ANIE201005075
MOST - No. M10755020001-07N5502-00110; No. A101954
KRIBB Research Initiative Program
ark:/67375/WNG-4HWM559C-3
istex:4BA4C6CAA859ABE62A67F4905A9D92AFF0BD3974
This research was supported by the KOSEF grant funded by MOST (No. M10755020001‐07N5502‐00110), the Korean Health Technology R&D Project, Ministry of Health, Welfare & Family Affairs (A101954), and the KRIBB Research Initiative Program.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201005075