Critical ischemic time for the rat ovary: Experimental study evaluating early histopathologic changes

The aim of the present study was to determine a critical ischemic time for ovary in an experimental study in rats. An experimental model using slip‐knot tying of all ovarian arteries and veins in cycling female rats was developed. Rat ovaries were tied using the technique through an explorative lapa...

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Bibliographic Details
Published inThe journal of obstetrics and gynaecology research Vol. 35; no. 2; pp. 330 - 334
Main Authors Coskun, Ayhan, Coban, Yusuf Kenan, Ciralik, Harun
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Publishing Asia 01.04.2009
Subjects
adnexal torsion
Animals
Female
Ischemia - pathology
ischemic time
Ovary - blood supply
rat ovary
Rats
Rats, Wistar
Reperfusion Injury - pathology
slip-knot technique
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Summary:The aim of the present study was to determine a critical ischemic time for ovary in an experimental study in rats. An experimental model using slip‐knot tying of all ovarian arteries and veins in cycling female rats was developed. Rat ovaries were tied using the technique through an explorative laparotomy. Complete ischemia times of 1, 2 and 3 h were used for the study. At the end of the ischemic times, the ovaries were harvested following 1 h of reperfusion. Histology indicated a gradually increased congestion correlating with the respective increased ischemic times. According to the present findings 2 h complete ischemia yields a significant injury. The model used in the present study may be used for complete ischemia–reperfusion injury of the rat ovary.
Bibliography:ark:/67375/WNG-NL4742MP-5
istex:5D6F9644B1A6E9225EED8DC1D1DEFA67CC4A511E
ArticleID:JOG874
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1341-8076
1447-0756
DOI:10.1111/j.1447-0756.2008.00874.x