Pituitary adenylate cyclase activating polypeptide and migraine

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with mo...

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Bibliographic Details
Published inAnnals of clinical and translational neurology Vol. 1; no. 12; pp. 1036 - 1040
Main Authors Zagami, Alessandro S., Edvinsson, Lars, Goadsby, Peter J.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.12.2014
Blackwell Publishing Ltd
Subjects
Annan klinisk medicin
Blood pressure
Brief Communications
Cats
Clinical Medicine
Grants
Headaches
Heart rate
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Migraine
Other Clinical Medicine
Patients
Pituitary gland
Polypeptides
Veins & arteries
United Kingdom > UK
Wales
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Summary:Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.
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Funding Information This work was supported by the National Health and Medical Research Council (NHMRC) of Australia, by grants from the Australian Brain Foundation, and the Swedish Research Council (grant no. 5958).
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.113