The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior

• Published in: Neuroscience Vol. 249; pp. 3 - 20
• Main Authors: Gulley, J.M, Juraska, J.M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Ltd 26.09.2013; Elsevier
• Subjects: Adolescent; Adolescent Behavior - drug effects; Adolescent Behavior - physiology; Adolescent Behavior - psychology; Adolescent Development - drug effects; Adolescent Development - physiology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Humans; Limbic System - drug effects; Limbic System - pathology; Nerve Net - drug effects; Nerve Net - pathology; neuroanatomy; Neurology; neurophysiology; Prefrontal Cortex - drug effects; Prefrontal Cortex - pathology; psychostimulants; Street Drugs - adverse effects; Vertebrates: nervous system and sense organs; young adult; magnetic resonance imaging; medial prefrontal cortex; psychostimulants; MRI; N-methyl- d-aspartate; prefrontal cortex; LTP; young adult; PFC; P; NAc; NMDA; postnatal day; basolateral amygdala; electroencephalography; corticotropin-releasing hormone; EEG; long-term depression; nucleus accumbens; mPFC; BLA; CRH; adolescent; neuroanatomy; neurophysiology; LTD; long-term potentiation; Human; Adolescent; Development; Behavior; N-methyl-d-aspartate
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.05.026

Highlights • Adolescence is a period of significant neurobiological and behavioral change. • Adolescence is a time when individuals first use drugs and alcohol. • Adolescents may be especially sensitive to drug-induced plasticity. • We review evidence suggesting adolescence is a period of high vulnerability.