Risk factors and possible mechanisms of saphenous vein graft failure after coronary artery bypass surgery

• Published in: Chinese medical journal Vol. 133; no. 13; pp. 1606 - 1608
• Main Authors: Song, Yan-Qiu, Xu, Yue, Guo, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins Ovid Technologies 05.07.2020; Wolters Kluwer Health; Wolters Kluwer
• Subjects: Atherosclerosis; Blood platelets; Cardiovascular disease; Cell adhesion & migration; Collagen; Coronary Angiography; Coronary Artery Bypass - adverse effects; Coronary vessels; Cytokines; Extracellular matrix; Growth factors; Homeostasis; Hyperplasia; Idea and Opinion; Inflammation; Ischemia; Kinases; Pathogenesis; Proteins; Risk Factors; Saphenous Vein; Shear stress; Stents; Surgical techniques; Thrombosis; Treatment Outcome; Vascular Patency; Veins & arteries
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000000872

[1] Vein graft failure can be affected by numerous potential risk factors, mainly including endothelial cell (EC) dysfunction, instantaneous shear stress change, structure of SVs, and surgical techniques. Growth factors (insulin-like growth factor, transforming growth factor, etc) can manage the remodeling of blood vessel walls. [4] These results indicate that the loss of EphB4 plays a role in vein graft adaptation, and stimulation of EphB4 function may be a candidate strategy for vein grafting in human clinical trials designed to inhibit venous neointimal hyperplasia. [7] SV distention pressure is significantly correlated with inflammatory markers, including toll-like receptors 2 and 4, platelet endothelial cell adhesion molecule (PECAM), vascular cell adhesion molecule, and intercellular cell adhesion molecule.