Signaling networks in human pluripotent stem cells

Graphical abstract Highlights ► Signaling in pluripotent stem cells is a complex, dynamic process. ► Multiple signaling pathways are required for maintenance of the stem cell state: Fgf/MAPK, TGFβ/SMAD2,3 and insulin/PI3K. ► These pathways are highly interactive and form a finely-balanced signaling...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 25; no. 2; pp. 241 - 246
Main Author Dalton, Stephen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Activins - metabolism
Animals
Cell Differentiation
Fibroblast Growth Factor 2 - metabolism
Humans
Insulin - metabolism
Internal Medicine
MAP Kinase Signaling System
Phosphatidylinositol 3-Kinases - metabolism
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction
Smad Proteins - metabolism
Transforming Growth Factor beta - metabolism
Wnt Signaling Pathway
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Summary:Graphical abstract Highlights ► Signaling in pluripotent stem cells is a complex, dynamic process. ► Multiple signaling pathways are required for maintenance of the stem cell state: Fgf/MAPK, TGFβ/SMAD2,3 and insulin/PI3K. ► These pathways are highly interactive and form a finely-balanced signaling network. ► Thresholds, temporal changes and combinatorial effects make important contributions to cell fate outcomes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2012.09.005