Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

• Published in: Oncogene Vol. 23; no. 24; pp. 4315 - 4329
• Main Authors: Stein, Gary S, Lian, Jane B, van Wijnen, Andre J, Stein, Janet L, Montecino, Martin, Javed, Amjad, Zaidi, Sayyed K, Young, Daniel W, Choi, Je-Yong, Pockwinse, Shirwin M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 24.05.2004
• Subjects: Bone and Bones - metabolism; Bone growth; Cbfa-1 protein; Cell cycle; Cell differentiation; Cell Differentiation - physiology; Cell Division - physiology; Cell growth; Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 2 Subunit; Core Binding Factor Alpha 3 Subunit; Core Binding Factor alpha Subunits; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Extracellular matrix; Gene expression; Gene Expression Regulation - physiology; Genotype & phenotype; Homeostasis; Mineralization; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Physiology; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Structure-function relationships; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; United States > US
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/sj.onc.1207676

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.