Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: Case report

A 12-year-old, intact female beagle exhibited symptoms of polyuria-polydipsia and hyperorexia for two months. Blood tests showed elevated asparate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatine kinase levels, as well as marked hypokalemia. The results of adrenocorticot...

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Published inJournal of Veterinary Medical Science Vol. 70; no. 3; pp. 317 - 320
Main Authors Machida, T.(Rakuno Gakuen Univ., Ebetsu, Hokkaido (Japan)), Uchida, E, Matsuda, K, Hirayama, K, Yoshii, K, Takiguchi, M, Taniyama, H
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.03.2008
Subjects
ADRENAL GLANDS
Adrenal Glands - diagnostic imaging
adrenocortical carcinoma
Adrenocortical Carcinoma - drug therapy
Adrenocortical Carcinoma - metabolism
Adrenocortical Carcinoma - pathology
Adrenocortical Carcinoma - veterinary
aldosterone
Aldosterone - blood
Animals
canine
CARCINOMA
CARCINOME
CHIEN
Corticosterone - blood
Dihydrotestosterone - analogs & derivatives
Dihydrotestosterone - therapeutic use
Dog Diseases - drug therapy
Dog Diseases - metabolism
Dog Diseases - pathology
DOGS
Fatal Outcome
Female
GLANDULAS SUPRARRENALES
GLUCOCORTICOIDE
GLUCOCORTICOIDES
GLUCOCORTICOIDS
HISTOPATHOLOGIE
HISTOPATHOLOGY
HISTOPATOLOGIA
Hydrocortisone - blood
MINERALOCORTICOIDE
MINERALOCORTICOIDES
MINERALOCORTICOIDS
PERRO
SURRENALE
Ultrasonography
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Summary:A 12-year-old, intact female beagle exhibited symptoms of polyuria-polydipsia and hyperorexia for two months. Blood tests showed elevated asparate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatine kinase levels, as well as marked hypokalemia. The results of adrenocorticotropic hormone stimulation test showed elevated cortisol, aldosterone and corticosterone concentrations. Abdominal ultrasonography confirmed a mass in the left adrenal gland. Masses were also seen in the liver and caudal vena cava. Diagnosis was a tumor of the adrenal cortex with metastases. Trilostane administration was initiated. The dog initially showed improved demeanor as a result of regulating hormone secretion. However, after 88 days, the dog weakened rapidly, before dying on the 117th day. Pathological findings confirmed a diagnosis of adrenocortical carcinoma.
Bibliography:2008005847
L70
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.70.317