Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study

• Published in: Journal of diabetes and metabolic disorders Vol. 19; no. 2; pp. 1593 - 1598
• Main Authors: Fardipour, Shohreh, Moein, Soheila, Teshnizi, Saeed Hosseini, Khaytian, Mahmoud, Qujeq, Durdi
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2020; BioMed Central Ltd; Nature Publishing Group
• Subjects: Analysis; Dextrose; Diabetes; Diabetes therapy; Diabetics; Diagnosis; Endocrinology; Glucose; Glycosylated hemoglobin; Medicine; Medicine & Public Health; Metabolic Diseases; Prediabetic state; Research Article; Type 2 diabetes; Uric acid; Diabetes mellitus; FBS; MASP1; Uric acid; Prediabetes; HbA1C; CMPF
• ISSN: 2251-6581; 2251-6581
• DOI: 10.1007/s40200-020-00697-9

Background The present study designed to evaluate the Serum levels of CMPF, MASP1 and UA in pre-diabetic subjects was compared to normal subjects . Methods This research is a case-control study. We studied 44 pre-diabetics with 44 normal subjects and were evaluated serum concentration of CMPF, Masp1 and U.Ain both groups andfurthermore serum concentration FPG, BUN, Cr, Cho, TG, HDLc, LDLc, AST, ALT, ALP, HbA1c was examined and correlation between of CMPF, Masp1 and U.Aand other parameters was statistically analyzed. Results Serum levels of MASP1, CMPF, fasting plasma glucose ( P  < 0.001)and uric acid ( P  < 0.002) were significantly increased in pre-diabetic subjects. In this study, a significant difference was found between MASP1 and CMPF in pre-diabetic subjects compared to normal subjects (P=0.005, r=0.291). There was also a significant difference between serum levels of MASP1 with HbA1C (P=0.01, r=0.269). Conclusion Serum levels of CMPF, MASP1 and uric acid were increased in pre-diabetic subjects. These parameters can be used as a biomarker for the diagnosis of pre-diabetes.