The indicative role of inflammatory index in the progression of periodontal attachment loss

• Published in: European journal of medical research Vol. 28; no. 1; pp. 1 - 287
• Main Authors: Zhang, Wenhao, Zhang, Yulong, Jin, Cong, Fang, Ruihan, Hua, Ruixue, Zang, Xiaodong, Zhang, Hengguo
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 17.08.2023; BioMed Central; BMC
• Subjects: Analysis; Bacterial infections; Blood; Blood cell count; Body mass index; Ethnicity; Gum disease; Hispanic Americans; Immune cell; Immunology; Leukocytes; Lymphocytes; Neutrophils; NHANES; Periodontal attachment loss; Race; Racial differences; Regression analysis; Surveys; Teeth; Variables; Viral infections; Viruses; WBC
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-023-01247-8

Objective To explore the forewarning immunological indicators during periodontal attachment loss progression in American adults. Methods A total of 5744 participants with periodontal attachment loss were enrolled from the National Health and Nutrition Examination Surveys (NHANES) 2009-2014. In which, dependent variable was the counts of teeth with severe attachment loss (depth of periodontal probing was above 5 mm). Independent variables were circulatory immunological indexes, including counts of white blood cells (WBC), Lymphocytes, Monocytes, Neutrophils, Eosinophils, and Basophils. The association among variables was examined using multivariable linear regression models, fitting with smoothing curves, and generalizing additive models. Results Based on the indicators of 5744 subjects, we found that severe attachment loss tended to occur in the elderly or males and was accompanied by higher WBC, Monocytes, and Neutrophils, as well as lower poverty-income ratio and educational qualification. WBC (above the inflection point: 6200 cells/[micro]L) and Neutrophils (above the inflection point: 3300 cells/[micro]L) counts were positively associated with attachment loss progression in each multivariable linear regression model. On subgroup analyses, stratified by sex and race, the positive correlation of WBC or Neutrophils with severe attachment loss was stable in both men and women, as well as in all races except blacks (WBC [beta] = - 0.0576, 95% CI - 0.1945 to 0.0793, Neutrophils [beta] = - 0.0527, 95% CI - 0.2285 to 0.1231). Conclusion Increasing WBC (above 6200 cells/[micro]L) and Neutrophils (above 3300 cells/[micro]L) counts were risk indicators of severe periodontal attachment loss among all races, except in blacks. Keywords: Periodontal attachment loss, Immune cell, NHANES, WBC, Neutrophils