Stem cell competition: finding balance in the niche

Highlights • Genetically equal stem cells compete for niche occupancy in multiple tissues. • Stochastic competition for niche access is important for stem cell fitness. • Mutated stem cells can gain a competitive advantage or disadvantage. • Stem cells with a competitive advantage can cause diseases...

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Bibliographic Details
Published inTrends in cell biology Vol. 23; no. 8; pp. 357 - 364
Main Authors Stine, Rachel R, Matunis, Erika L
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2013
Subjects
Animals
cancer
competition
Drosophila melanogaster - cytology
Hematopoiesis
Mammals - metabolism
niche
Organ Specificity
Pathology
stem cell
Stem Cell Niche
Stem Cells - cytology
competition
niche
cancer
stem cell
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Summary:Highlights • Genetically equal stem cells compete for niche occupancy in multiple tissues. • Stochastic competition for niche access is important for stem cell fitness. • Mutated stem cells can gain a competitive advantage or disadvantage. • Stem cells with a competitive advantage can cause diseases or niche defects.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.03.001