A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients

• Published in: Anais brasileiros de dermatología Vol. 93; no. 1; pp. 54 - 58
• Main Authors: Aly, Dalia Gamal, Salem, Samar Abdallah, Amr, Khalda Sayed, El-Hamid, Mahmoud Fawzy Abd
• Format: Journal Article
• Language: English
• Published: Spain Elsevier España, S.L.U 01.01.2018; Sociedade Brasileira de Dermatologia
• Subjects: Adolescent; Adult; Aged; Case-Control Studies; Child; DERMATOLOGY; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Glutathione S-Transferase pi; Glutathione Transferase - genetics; Humans; Investigation; Male; Middle Aged; Oxidative stress; Polymorphism, Genetic - genetics; Polymorphism, single nucleotide; Vitiligo; Vitiligo - genetics; Young Adult; Oxidative stress; Vitiligo; Glutathione S-Transferase pi; Polymorphism, single nucleotide
• ISSN: 0365-0596; 1806-4841; 1806-4841
• DOI: 10.1590/abd1806-4841.20185796

The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egyptian patients with generalized vitiligo. This study included 122 vitiligo patients and 200 healthy controls that were age, and gender matched. Assessment of GSTM1/T1 gene polymorphisms was done using a multiplex polymerase chain reaction (PCR). Increased odds of generalized vitiligo was observed with the null genotypes of GSTM1 and GSTT1 polymorphisms (P<0.05). Controls with GSTM1 null/GSTT1+ heterozygosis presented with a 2.97 odds protection from having generalized vitiligo (OR=2.97, 95%CI=1.1-7.7) (P=0.02) compared with patients. Small sample size of patients. This study showed a significant trend towards an association with the combination of the GSTM1/GSTT1 double null polymorphism and generalized vitiligo. Individuals with GSTM1 null/GSTT1+ heterozygosis have a 2.97 odds protection from having generalized vitiligo compared with patients. It was is the first time, to our knowledge, that such an association has been reported.