Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidat...

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Published inJournal of hematology and oncology Vol. 16; no. 1; pp. 1 - 33
Main Authors Jin, Hao-Ran, Wang, Jin, Wang, Zi-Jing, Xi, Ming-Jia, Xia, Bi-Han, Deng, Kai, Yang, Jin-Lin
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 12.09.2023
BioMed Central
BMC
Subjects
Biosynthesis
Breast cancer
Cancer
Cancer progression
Cancer therapies
Care and treatment
Cholesterol
Dehydrogenases
Development and progression
Fatty acids
Glycerol
Hematology
Immune response
Kinases
Lipid metabolism
Lipid peroxidation
Lipids
Lymphocytes
Metabolism
Metabolites
Metastasis
Oncology
Oxidation
Phenotypes
Physiological aspects
Review
Stromal cells
Targeted therapy
Therapeutic targets
Tumor cells
Tumor microenvironment
Tumors
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Summary:Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic reprogramming, which further affects tumor functional phenotypes and immune responses. Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid metabolic reprogramming in cancer, (2) summarize the lipid metabolic landscapes within stromal cells and immune cells in the tumor microenvironment, and clarify their roles in tumor progression, and (3) summarize potential therapeutic targets for lipid metabolism, and highlight the potential for combining such approaches with other anti-tumor therapies to provide new therapeutic opportunities for cancer patients.
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ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-023-01498-2