The Significance of 8-oxoGsn in Aging-Related Diseases

• Published in: Aging and disease Vol. 11; no. 5; pp. 1329 - 1338
• Main Authors: Zhang, Xinmu, Li, Lin
• Format: Journal Article
• Language: English
• Published: JKL International 01.10.2020; JKL International LLC
• Subjects: Aging (Biology); Disease age factors; Genetic aspects; Guanosine; Health aspects; Oxidative stress; Review; RNA; China
• ISSN: 2152-5250; 2152-5250
• DOI: 10.14336/AD.2019.1021

Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative damage is an important mechanism involved in aging. The latest discovery pertaining to oxidative damage is that 8-oxoGsn (8-oxo-7,8-dihydroguanosine), an oxidative damage product of RNA, can represent the level of oxidative stress. The significance of RNA oxidative damage to aging has not been fully explained, but the relationship between the accumulation of 8-oxoGsn, a marker of RNA oxidative damage, and the occurrence of diseases has been confirmed in many aging-related diseases. Studying the aging mechanism, monitoring the aging level of the body and exploring the corresponding countermeasures are of great significance for achieving healthy aging and promoting public health and social development. This article reviews the progress of research on 8-oxoGsn in aging-related diseases. Key words: RNA oxidative damage, 8-oxoGsn, aging-related diseases