A minimal view of single-particle imaging with X-ray lasers

The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining the three-dimensional structure of biomolecules without crystallization. However, the complexity of imaging a sample's structure from ver...

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Published inPhilosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 369; no. 1647; p. 20130328
Main Author Loh, N. Duane
Format Journal Article
LanguageEnglish
Published England The Royal Society 17.07.2014
Subjects
Algorithms
Bioimaging
Coherent Diffraction
Electrons
Lasers
Models, Theoretical
Molecular Conformation
Part II: Technique development
Review
Single Particle Imaging
Time Factors
X-Ray Diffraction - methods
X-Ray Free-Electron Laser
single particle imaging
X-ray free-electron laser
coherent diffraction
bioimaging
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Abstract The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining the three-dimensional structure of biomolecules without crystallization. However, the complexity of imaging a sample's structure from very many of its noisy and incomplete diffraction data can be daunting. In this review, we introduce a simple analogue of this imaging workflow, use it to describe a structure reconstruction algorithm based on the expectation maximization principle, and consider the effects of extraneous noise. Such a minimal model can aid experiment and algorithm design in future studies.
AbstractList The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining the three-dimensional structure of biomolecules without crystallization. However, the complexity of imaging a sample's structure from very many of its noisy and incomplete diffraction data can be daunting. In this review, we introduce a simple analogue of this imaging workflow, use it to describe a structure reconstruction algorithm based on the expectation maximization principle, and consider the effects of extraneous noise. Such a minimal model can aid experiment and algorithm design in future studies.
Author Loh, N. Duane
AuthorAffiliation 2 PULSE Institute, SLAC National Accelerator Laboratory , Menlo Park, CA 94025 , USA
1 Center for Bioimaging Sciences and Department of Biological Sciences , National University of Singapore , 14 Science Drive 4, Singapore 117411
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  organization: Center for Bioimaging Sciences and Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117411 PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA
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Keywords single particle imaging
X-ray free-electron laser
coherent diffraction
bioimaging
Language English
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Snippet The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining...
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SubjectTerms Algorithms
Bioimaging
Coherent Diffraction
Electrons
Lasers
Models, Theoretical
Molecular Conformation
Part II: Technique development
Review
Single Particle Imaging
Time Factors
X-Ray Diffraction - methods
X-Ray Free-Electron Laser
Title A minimal view of single-particle imaging with X-ray lasers
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