Ultrastructural analysis of rat ventrolateral periaqueductal gray projections to the A5 cell group

• Published in: Neuroscience Vol. 224; pp. 145 - 159
• Main Authors: Bajic, D, Van Bockstaele, E.J, Proudfit, H.K
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 08.11.2012; Elsevier
• Subjects: Anatomy; Animals; anterograde tracer; Biological and medical sciences; biotinylated dextran amine; Central nervous system; electron microscopy; Fundamental and applied biological sciences. Psychology; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Neural Pathways - ultrastructure; Neurology; Neurons - ultrastructure; Periaqueductal Gray - ultrastructure; Rats; Rats, Sprague-Dawley; synapse; tyrosine hydroxylase; ultrastructure; Vertebrates: nervous system and sense organs; Tris–buffered saline; PHA-L; tyrosine hydroxylase-immunoreactivity; phosphate buffer; phosphate-buffered saline; BSA; caudal ventrolateral medulla; central medial medulla; electron microscopy; Phaseolus vulgaris leucoagglutinin; biotinylated dextran amine; PBS; CMM; rostral ventrolateral medulla; RVLM; TH-ir; TBS; CVLM; GAD; synapse; ultrastructure; tyrosine hydroxylase; PB; TH; anterograde tracer; PAG; BDA; bovine serum albumin; glutamate decarboxylase; periaqueductal gray; Rat; Enzyme; Rodentia; Central nervous system; Projection; Tyrosine 3-monooxygenase; Encephalon; Dextran; Vertebrata; Synapse; Mammalia; ultra-structure; Periaqueductal gray matter; Ultrastructure; Animal; Oxidoreductases
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.08.021

Highlights ► Neurons of the A5 cell group receive monosynaptic input from the ventrolateral periaqueductal gray (PAG). ► The majority of synapses are with non-catecholaminergic dendrites (40%) and other axons (45%). ► The minority of synapses are with noradrenergic dendrites of the A5 cell group (10%).