Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities

Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Me...

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Published inMetabolites Vol. 11; no. 9; p. 587
Main Authors Hyvärinen, Eelis, Savolainen, Minttu, Mikkonen, Jopi J. W., Kullaa, Arja M.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 31.08.2021
MDPI
Subjects
Biomarkers
Chromatography
Diagnosis
Exocrine glands
mass spectrometry
Metabolism
Metabolites
Metabolomics
Mouth
Neurodegenerative diseases
NMR
NMR spectrometry
Nuclear magnetic resonance
oral disease
Oral diseases
Periodontitis
Physiology
Principal components analysis
Review
Saliva
systemic disease
Systemic diseases
Tongue
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Summary:Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Metabolomics is starting to emerge as a viable method for assessing the salivary metabolites which are generated by the biochemical processes in elucidating the pathways underlying different oral and systemic diseases. In oral diseases, salivary metabolomics has concentrated on periodontitis and oral cancer. Salivary metabolites of systemic diseases have been investigated mostly in the early diagnosis of different cancer, but also neurodegenerative diseases. This mini-review article aims to highlight the challenges and possibilities of salivary metabolomics from a clinical viewpoint. Furthermore, applications of the salivary metabolic profile in diagnosis and prognosis, monitoring the treatment success, and planning of personalized treatment of oral and systemic diseases are discussed.
Bibliography:ObjectType-Article-2
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11090587