The projection and synaptic organisation of NTS afferent connections with presympathetic neurons, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus

• Published in: Neuroscience Vol. 219; no. 1-2; pp. 48 - 61
• Main Authors: Affleck, V.S, Coote, J.H, Pyner, S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 06.09.2012; Elsevier; Elsevier Science
• Subjects: Afferent Pathways - anatomy & histology; Afferent Pathways - metabolism; Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; gamma amino butyric acid; gamma-Aminobutyric Acid - biosynthesis; Immunohistochemistry; Male; Neurology; Neurons - cytology; Neurons - metabolism; nitric oxide; Nitric Oxide Synthase Type I - biosynthesis; nucleus tractus solitarius; Paraventricular Hypothalamic Nucleus - anatomy & histology; Paraventricular Hypothalamic Nucleus - metabolism; paraventricular nucleus of the hypothalamus; Rats; Rats, Wistar; Solitary Nucleus - anatomy & histology; Solitary Nucleus - metabolism; spinally projecting presympathetic neurons; Vertebrates: nervous system and sense organs; FG; NO; spinally projecting presympathetic neurons; biotin dextran amine; HRP; myocardial infarction; normal goat serum; fluorogold; phosphate buffer; PVN; PFA; NTS; SPN; vGLUT2; horseradish peroxidase; NHS; cholera B toxin subunit; MI; paraformaldehyde; diaminobenzidine; heart failure; nitric oxide; rostral ventrolateral medulla; intraperitoneal; RVLM; DAB; TBS; vesicular glutamate transporter 2; IP; neuronal nitric oxide synthase; nucleus tractus solitarius; gamma aminobutyric acid; paraventricular nucleus of the hypothalamus; normal horse serum; Tris buffered saline; CTB; PB; sympathetic preganglionic neurons; gamma amino butyric acid; nNOS; GABA; NGS; BDA; HF; Enzyme; Central nervous system; Projection; Hypothalamus; Paraventricular nucleus; Nitric-oxide synthase; Encephalon; Solitary nucleus; Aminoacid; Nitric oxide; Oxidoreductases; Gabaergic neuron
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.070

Highlights ► Ascending NTS fibres target PVN-associated neurons. ► Suggest glutamate as the neurotransmitter. ► Anatomical basis for the different functions of cardiovascular receptors.