The clinical and immunological spectrum of American cutaneous leishmaniasis

American cutaneous leishmaniasis is characterized by a spectrum of clinical manifestations. These include localized, often self-healing single lesions, intermediate forms which frequently produce mucosal lesions and often show exaggerated delayed-type hypersensitivity (DTH), and the rare diffuse cut...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 87; no. 4; pp. 444 - 448
Main Authors Convit, J., Ulrich, M., Fernández, C.T., Tapia, F.J., Cáceres-Dittmar, G., Castés, M., Rondón, A.J.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.1993
Royal Society of Tropical Medicine and Hygiene
Elsevier
Subjects
Animals
Antigens, Protozoan - immunology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Female
Human protozoal diseases
Humans
Hypersensitivity, Delayed - immunology
Infectious diseases
Leishmania
Leishmania mexicana - immunology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - pathology
Leishmaniasis, Diffuse Cutaneous - immunology
Leishmaniasis, Mucocutaneous - immunology
Leshmaniasis
Lymphocyte Activation - immunology
Male
Medical sciences
Parasitic diseases
Protozoal diseases
Skin - immunology
Skin - pathology
Tropical medicine
South America
Venezuela
America
Infection
Human
Symptomatology
Skin disease
Protozoal disease
Immune response
Immunological investigation
Cellular immunity
Skin
Leishmaniasis
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Summary:American cutaneous leishmaniasis is characterized by a spectrum of clinical manifestations. These include localized, often self-healing single lesions, intermediate forms which frequently produce mucosal lesions and often show exaggerated delayed-type hypersensitivity (DTH), and the rare diffuse cutaneous leishmaniasis in which no reaction of protective cell-mediated immunity or DTH can be demonstrated. Clinical, pathological and immunological studies have begun to unravel some of the mechanisms associated with different disease manifestations, dependent on complex interactions between the host immune response, measured in terms of indices including lymphocyte subsets and lymphokines in vitro and within active lesions, and different species of Leishmania.
Bibliography:istex:DC8BDCB3084D3644ECF58D3023497C1353551A26
Address for correspondence: Dr Jacinto Convit, Instituto de Biomedicina, Apartado 4043, Caracas 1010A, Venezuela.
ark:/67375/HXZ-SHD9HPPB-B
Clinical studies and pathology
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ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(93)90030-T