INHIBITORY EFFECT OF TANNINS ON DIRECT-ACTING MUTAGENS

Remarkably strong inhibition of mutagenicity of 3-hydroxyamino-1-methyl-5H-pyrido [4, 3-b] indole due to direct action of tannins on the mutagen was found. Strong inhibition of mutagenicity of 7β, 8α-dihydroxy-9α, 10α-epoxy-7, 8, 9, 10-tetrahydrobenzo [α] pyrene was observed for the extract of Geran...

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Published inChemical & pharmaceutical bulletin Vol. 32; no. 9; pp. 3755 - 3758
Main Authors Okuda, Takuo, Mori, Kazuko, Hayatsu, Hikoya
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1984
Maruzen
Subjects
Biological and medical sciences
Chemical mutagenesis
Geranium thunbergii
Medical sciences
Mutagenicity Tests
Mutagens - antagonists & inhibitors
Salmonella typhimurium - genetics
Tannins - pharmacology
Toxicology
Direct acting mutagen
Vegetals
Tannin
Mutagenicity testing
Japan
Medicinal plant
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Summary:Remarkably strong inhibition of mutagenicity of 3-hydroxyamino-1-methyl-5H-pyrido [4, 3-b] indole due to direct action of tannins on the mutagen was found. Strong inhibition of mutagenicity of 7β, 8α-dihydroxy-9α, 10α-epoxy-7, 8, 9, 10-tetrahydrobenzo [α] pyrene was observed for the extract of Geranium thunbergii.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.3755