Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates

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Bibliographic Details
Published inToxicology (Amsterdam) Vol. 338; pp. 47 - 58
Main Authors Hartman, Jessica H, Martin, H. Cass, Caro, Andres A, Pearce, Amy R, Miller, Grover P
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 02.12.2015
Subjects
4-Nitrophenol
Aniline
Aniline Compounds - metabolism
Animals
Biotransformation
Catalytic Domain
Cooperativity
CYP2E1
Cytochrome P-450 CYP2E1 - metabolism
Emergency
Endoplasmic Reticulum - enzymology
Enzymes
Female
Kinetics
Liver - enzymology
Localization
Metabolism
Mitochondria, Liver - enzymology
Mitochondrial transport
Models, Biological
Nitrophenols - metabolism
Oxidation
Oxidation-Reduction
Position (location)
Protein Binding
Protein Transport
Rats, Sprague-Dawley
Reaction kinetics
Styrene
Styrene - metabolism
Styrenes
Substrate Specificity
4-Nitrophenol
Aniline
cytochrome P450 (specific isoforms)
Styrene
CYP
CYP2E1
Cooperativity
Mitochondrial transport
SDHA
SERCA
sarco/endoplasmic reticulum Ca 2+-ATPase
succinate dehydrogenase
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Summary:Graphical abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to the work.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2015.10.001