Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 10; p. 1374
• Main Authors: Moghadam, Ebrahim Rahmani, Ang, Hui Li, Asnaf, Sholeh Etehad, Zabolian, Amirhossein, Saleki, Hossein, Yavari, Mohammad, Esmaeili, Hossein, Zarrabi, Ali, Ashrafizadeh, Milad, Kumar, Alan Prem
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.09.2020; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Analgesics; Antimitotic agents; Antineoplastic agents; Antineoplastic Agents - therapeutic use; Antioxidants; Antioxidants - therapeutic use; Antitumor activity; Antitumor agents; Apoptosis; Bioavailability; Cancer therapies; cancer therapy; Carbon; Cell cycle; Cell proliferation; Chemotherapy; chrysin; Dosage and administration; Drug resistance; Drug Resistance, Neoplasm - drug effects; flavonoid; Flavonoids; Flavonoids - therapeutic use; Gene expression; Humans; Inflammation; MAP kinase; Metabolism; Metabolites; Metastasis; MicroRNAs - genetics; miRNA; Morbidity; nanoparticle; Nanoparticles; Natural products; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Neuroprotection; NF-κB protein; Patient outcomes; Pharmacokinetics; Phytochemicals; Public health; Receptor, Notch1 - genetics; Review; Signal Transduction - drug effects; Stat3 protein; STAT3 Transcription Factor - genetics; Tumor necrosis factor-TNF; Iran; cancer therapy; nanoparticle; flavonoid; chrysin; chemotherapy
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom10101374

Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.